Research at University

Importance of Research in Advancement of Dentistry

To maintain our solutions at the most advanced level, we collaborate with many universities from several countries.

Together with the University of Zürich, we have optimized our template design to the requirements of such outstanding surgeons as Prof. Dr. Christoph Hämmerle and Prof. Dr. Ronald Jung. Together with Prof. Dr. David Schneider, we developed software to analyze and better understand long-term results from soft tissue augmentation and reduction.

With the University of Bern (Prof. Dr. Michael Bornstein / Prof. Dr. Valerie Suter) we implemented procedures in our SMOP system for sketching 3D volumes into the radiological 3D picture of the patient yaw. The goal was to mark and measure cysts and other anomalies. These procedures can now be used to mark and design bone blocks to be exported for manufacturing.

Below is a list of all universities we collaborate with and a list of publications involving Swissmeda/SMOP.

Research Partners

Name Location
Universität Zürich Switzerland
Universität Bern Switzerland
Université de Genève Switzerland
Universität Basel Switzerland
Universität Ulm Germany
Universitätsklinikum Freiburg Germany
Goethe-Universität Frankfurt am Main Germany
Universidad Complutense de Madrid Spain


Implant Planning and Template Guided Surgery:

Clinical Implant Dentistry and Related Research 2015. E-pub ahead of print
“Accuracy of 3D Printed Templates for Guided Implant Placement Based on Matching a Surface Scan with CBCT”
Kernen M, Benic G, Payer M, Schär A, Müller-Gerbl M, Filippi A, Kühl S
Clin Oral Implants Res. 2009 Sep;20 Suppl 4:73-86. doi: 10.1111/j.1600-0501.2009.01788.x
“A systematic review on the accuracy and the clinical outcome of computer-guided template-based implant dentistry.”
Schneider D, Marquardt P, Zwahlen M, Jung RE
Swiss Dent J. 2014;124(3):305-23
“Template guided surgery with the open-access software "smop".”
Kurt BR
Clin Implant Dent Relat Res. 2018 Aug;20(4):541-549. doi: 10.1111/cid.12614. Epub 2018 Apr 25
“Accuracy of the match between cone beam computed tomography and model scan data in template-guided implant planning: A prospective controlled clinical study.”
Schnutenhaus S, Gröller S, Luthardt RG, Rudolph H
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Apr;121(4):e72-9. doi: 10.1016/j.oooo.2015.12.012. Epub 2016 Jan 4
“Retrospective study to determine the accuracy of template-guided implant placement using a novel nonradiologic evaluation method.”
Schnutenhaus S, Edelmann C, Rudolph H, Luthardt RG
Clin Oral Investig. 2018 Jul;22(6):2363-2372. doi: 10.1007/s00784-018-2339-8. Epub 2018 Jan 22
“3D accuracy of implant positions in template-guided implant placement as a function of the remaining teeth and the surgical procedure: a retrospective study.”
Schnutenhaus S, Edelmann C, Rudolph H, Dreyhaupt J, Luthardt RG
Int J Comput Dent. 2018;21(2):97-105
“Precision of sleeveless 3D drill guides for insertion of one-piece ceramic implants: a prospective clinical trial”
Schnutenhaus S, von Koenigsmarck V, Blender S, Ambrosius L, Luthardt RG, Rudolph H
Int J Environ Res Public Health. 2018 Oct 25;15(11). pii: E2361. doi: 10.3390/ijerph15112361
“Full in-Office Guided Surgery with Open Selective Tooth-Supported Templates: A Prospective Clinical Study on 20 Patients.”
Mangano FG, Hauschild U, Admakin O
Clin Oral Implants Res. 2015 Mar;26(3):320-5. doi: 10.1111/clr.12327. Epub 2014 Jan 18
“In-vitro evaluation of the tolerance of surgical instruments in templates for computer-assisted guided implantology produced by 3-D printing.”
Schneider D, Schober F, Grohmann P, Hammerle CH, Jung RE
In production
“Efficiency of conventional and computer-assisted, template guided implant planning and placement - a randomized controlled clinical trial.”
Schneider D, Sancho M, Schober F, Jung RE, Mühlemann S, Benic G, Hämmerle CHF

Volume Compare and Volume Designer:

Int J Implant Dent. 2018 Jun 5;4(1):17. doi: 10.1186/s40729-018-0128-4.
“3D-evaluation of the maxillary sinus in cone-beam computed tomography.”
Luz J, Greutmann D, Wiedemeier D, Rostetter C, Rücker M, Stadlinger B
In production
“Prospective clinical study for 3-D volumetric evaluation of two techniques for periimplant GBR procedures”
Schneider D, Thoma D, Jung RE, Hämmerle CHF in progress
Int J Periodontics Restorative Dent. 2014 May-Jun;34(3):333-43. doi: 10.11607/prd.1842
“Zirconia ceramic single-retainer resin-bonded fixed dental prostheses (RBFDPs) after 4 years of clinical service: a retrospective clinical and volumetric study.”
Sailer I, Hämmerle CH
Clin Implant Dent Relat Res. 2015 Feb;17(1):71-82. doi: 10.1111/cid.12076. Epub 2013 Apr 30
“The socket-shield technique: first histological, clinical, and volumetrical observations after separation of the buccal tooth segment – a pilot study.”
Bäumer D, Zuhr O, Rebele S, Schneider D, Schupbach P, Hürzeler M
J Clin Periodontol. 2013 Jul;40(7):721-7. doi: 10.1111/jcpe.12111. Epub 2013 May 5
“Dimensional alterations of extraction sites after different alveolar ridge preservation techniques - a volumetric study.”
Thalmair T, Fickl S, Schneider D, Hinze M, Wachtel H
J Clin Periodontol. 2014 Jun;41(6):582-92. doi: 10.1111/jcpe.12178. Epub 2013 Nov 10
“Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: a RCT using 3D digital measuring methods. Part I. Clinical and patient-centred outcomes.”
Zuhr O, Rebele SF, Schneider D, Jung RE, Hürzeler MB
J Clin Periodontol. 2013 Jan;40(1):90-8. doi: 10.1111/jcpe.12027. Epub 2012 Nov 19
“Radiographic evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial.”
Jung RE, Philipp A, Annen BM, Signorelli L, Thoma DS, Hämmerle CH, Attin T, Schmidlin P
J Clin Periodontol. 2014 Jun;41(6):593-603. doi: 10.1111/jcpe.12254
“Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: a RCT using 3D digital measuring methods. Part II. Volumetric studies on healing dynamics and gingival dimensions.”
Rebele SF, Zuhr O, Schneider D, Jung RE, Hürzeler MB
J Clin Periodontol. 2016 Dec;43(12):1124-1131. doi: 10.1111/jcpe.12624. Epub 2016 Oct 25
“Palatal wound healing using a xenogeneic collagen matrix - histological outcomes of a randomized controlled clinical trial.”
Thoma DS, Hilbe M, Bienz SP, Sancho-Puchades M, Hämmerle CH, Jung RE
J Clin Periodontol. 2017 Feb;44(2):178-184. doi: 10.1111/jcpe.12651. Epub 2017 Jan 17
“Volumetric changes at pontic sites with or without soft tissue grafting: a controlled clinical study with a 10-year follow-up.”
Bienz SP, Sailer I, Sanz-Martín I, Jung RE, Hämmerle CH, Thoma DS
J Clin Periodontol. 2017 Apr;44(4):446-453. doi: 10.1111/jcpe.12697. Epub 2017 Feb 11
“Randomized controlled clinical study comparing a volume-stable collagen matrix to autogenous connective tissue grafts for soft tissue augmentation at implant sites: linear volumetric soft tissue changes up to 3 months.”
Zeltner M, Jung RE, Hämmerle CH, Hüsler J, Thoma DS
J Clin Periodontol. 2018 Apr;45(4):484-494. doi: 10.1111/jcpe.12860. Epub 2018 Jan 31
“Volumetric changes following ridge preservation or spontaneous healing and early implant placement with simultaneous guided bone regeneration.”
Naenni N, Bienz SP, Muñoz F, Hämmerle CHF, Jung RE, Thoma DS
J Clin Periodontol. 2014 Jun;41(6):612-7. doi: 10.1111/jcpe.12246. Epub 2014 Mar 26
“Labial soft tissue volume evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial.”
Schneider D, Schmidlin PR, Philipp A, Annen BM, Ronay V, Hämmerle CH, Attin T, Jung RE
Clin Oral Investig. 2018 Jul 17. doi: 10.1007/s00784-018-2552-5. [Epub ahead of print]
“Is the pneumatisation of the maxillary sinus following tooth loss a reality? A retrospective analysis using cone beam computed tomography and a customised software program.”
Schriber M, Bornstein MM, Suter VGA
J Clin Periodontol. 2017 Aug;44(8):842-853. doi: 10.1111/jcpe.12747. Epub 2017 Jul 26
“Hard and soft tissue integration of immediate and delayed implants with a modified coronal macrodesign: Histological, micro-CT and volumetric soft tissue changes from a pre-clinical in vivo study.”
Sanz-Martin I, Vignoletti F, Nuñez J, Permuy M, Muñoz F, Sanz-Esporrín J, Fierravanti L, Shapira L, Sanz M
J Clin Periodontol. 2010 Jul;37(7):659-66. doi: 10.1111/j.1600-051X.2010.01581.x
“Soft tissue volume augmentation by the use of collagen-based matrices: a volumetric analysis.”
Thoma DS, Jung RE, Schneider D, Cochran DL, Ender A, Jones AA, Görlach C, Uebersax L, Graf-Hausner U, Hämmerle CH
Clin Oral Implants Res. 2011 Jan;22(1):28-37. doi: 10.1111/j.1600-0501.2010.01987.x. Epub 2010 Oct 6
“Volume gain and stability of peri-implant tissue following bone and soft tissue augmentation: 1-year results from a prospective cohort study.”
Schneider D, Grunder U, Ender A, Hämmerle CH, Jung RE
Clin Oral Implants Res. 2015 Jun;26(6):688-95. doi: 10.1111/clr.12368. Epub 2014 Apr 10
“Soft tissue augmentation of ridge defects in the maxillary anterior area using two different methods: a randomized controlled clinical trial.”
Akcalı A, Schneider D, Ünlü F, Bıcakcı N, Köse T, Hämmerle CH
J Clin Periodontol. 2018 Apr;45(4):504-512. doi: 10.1111/jcpe.12865. Epub 2018 Feb 1
“Non-interventional 1-year follow-up study of peri-implant soft tissues following previous soft tissue augmentation and crown insertion in single-tooth gaps.”
Huber S, Zeltner M, Hämmerle CHF, Jung RE, Thoma DS
Clin Oral Implants Res. 2017 Feb;28(2):219-225. doi: 10.1111/clr.12786. Epub 2016 Feb 8
“Guided bone regeneration and abutment connection augment the buccal soft tissue contour: 3-year results of a prospective comparative clinical study.”
Benic GI, Ge Y, Gallucci GO, Jung RE, Schneider D, Hämmerle CH
Clin Oral Implants Res. 2018 Oct;29(10):986-995. doi: 10.1111/clr.13365. Epub 2018 Sep 23
“A novel methodological approach using superimposed Micro-CT and STL images to analyze hard and soft tissue volume in immediate and delayed implants with different cervical designs.”
Sanz-Martín I, Permuy M, Vignoletti F, Nuñez J, Muñoz F, Sanz M1
Int J Periodontics Restorative Dent. 2018;38(Suppl):s49-s57. doi: 10.11607/prd.ds2018s
“A Randomized Controlled Clinical Trial Comparing Conventional and Computer-Assisted Implant Planning and Placement in Partially Edentulous Patients. Part 1: Clinician-Related Outcome Measures.”
Schneider D, Sancho-Puchades M, Benic GI, Hämmerle CH, Jung RE
J Clin Periodontol. 2012 Feb;39(2):157-65. doi: 10.1111/j.1600-051X.2011.01823.x. Epub 2011 Dec 6
“Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds - a randomized study in humans.”
Thoma DS, Sancho-Puchades M, Ettlin DA, Hämmerle CH, Jung RE